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Author

Jianhua Wang

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Open access Sep 2026

Single-cell multiomic QTL mapping reveals state-dependent genetic regulation and associated gene during cellular senescence

How cellular senescence reshapes inherited regulatory effects across chromatin and transcription, and eventually contribute to non-coding risk loci of complex diseases, remains elusive. We generated single-cell multiome ATAC-RNA profiles from proliferating and replicatively senescent primary HUVECs derived from 100 gen...

Xian-Fu Yi, Xue-Qi Wang, Kun-Lun Liu et al. · 0 citations

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