Aug 2026
In situ macrophage reprogramming via micropatch engineering for safe and effective antitumor adoptive cell therapy.
Adoptive cell therapy with macrophages holds great promise for treating solid tumors, but its clinical impact has been limited. The problem is twofold: the immunosuppressive tumor microenvironment quickly silences the anti-tumor activity of transferred cells, and systemic activation strategies often provoke off-target...
Yongkang Xu, Lei Cao, Yuyan Zhou et al.
· Science Bulletin · 0 citations