Open access
Jul 2026
RNF220 safeguards meiotic synapsis and male fertility by antagonizing SYCE1 ubiquitination
A homozygous mutation in RNF220 , encoding a RING-type E3 ubiquitin ligase, is associated with male infertility featuring small-headed sperm, but the precise roles and mechanisms of RNF220 in spermatogenesis remain elusive. Here, we explored the function of RNF220 in spermatogenesis using a Stra8-Cre-mediated...
Jing-Mei Cha, Huijuan Lin, Yingqian Xia et al.
· Cell Death & Disease · 0 citations