Author

Jianzhong Du

2 papers indexed here

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Sep 2026

Coordination of Oligonucleotides into Enzyme-Mimetic Nanostructures for Ameliorating Osteoarthritis through Intervening in Articular Cartilage and Subchondral Bone.

Osteoarthritis (OA) is a common degenerative joint disease, characterized by oxidative stress, excessive inflammatory responses, cartilage matrix degradation, and subchondral bone loss. However, a therapeutic strategy that simultaneously addresses these interconnected pathologies remains elusive in current nanomedicine...

Xuan-Ran Yang, Jian-Hua Li, Jing-Jing Jiang et al. · ACS Applied Materials and In... · 0 citations

Aug 2026

Coordinated circRNA Silencing and Chemotherapy by pH-Responsive Nanoparticles Reprogram Cell Death in Drug-Resistant Osteosarcoma.

Chemoresistance remains a major clinical challenge in osteosarcoma, primarily driven by inefficient drug delivery and the evasion of cell death. Here, a multifunctional poly(β-amino ester) (pBAE)-based therapeutic delivery system was developed for simultaneous codelivery of small interfering RNA (siRNA) and doxorubicin...

Xingkai Wang, Caihong Chen, Xiaolong Ma et al. · Nano letters (Print) · 0 citations