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Author

Jiaoe Chen

2 papers indexed here

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Open access Jan 2026

GPR39 Suppresses Ferroptosis via the Nrf2/SLC7A11 Axis and Reduces the Sensitivity of Colorectal Cancer to Anti‐PD‐1 Immunotherapy

In vivo, GPR39 knockdown significantly potentiated the antitumor activity of PD‐1 blockade, as evidenced by suppressed tumor progression accompanied by enhanced infiltration of CD8+ T cells, whereas ferroptosis inhibition abrogated these effects.

Cong Zhou, Xiao-Ling Fang, Jia-Ying Lin et al. · 0 citations
Open access Jul 2026

Lachnospiraceae and Its Metabolite Malate Act in Concert to Repair Gut Microbiota Imbalance and Block Colorectal Cancer Progression.

BACKGROUND Gut microbiota dysbiosis is a crucial driver of the initiation and progression of colorectal cancer (CRC), where functional gut microbes and their metabolites play key roles in the microecological regulation of CRC. Currently, the association between Lachnospiraceae and CRC progression, as well as the underl...

Zejun Fang, Yanyan Hu, Minjing Zhu et al. · 0 citations

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