Review
Open access
Aug 2026
Biologic prodrugs: inactive protein and peptide drugs and drug conjugates with targeted activation
Examples discussed show biologic prodrugs as a versatile platform that selectively responds to physiological and environmental triggers, enabling enhanced spatial and temporal control of drug activation and thereby limiting systemic toxicity and other challenges associated with biologics.
Benazir Oluoch, Samantha Marcotte, D. Miele et al.
· AAPS Open · 0 citations