Open access
Aug 2026
JUND-DNAJB1-p21 axis drives fibroblast senescence to recruit CD4⁺ T cells in salivary gland pathogenesis of Sjögren’s disease
Advanced age is a recognized risk factor for primary Sjögren’s disease (pSjD), suggesting a role for aging-related mechanisms in its pathogenesis. However, whether cellular senescence directly drives autoimmune inflammation and glandular dysfunction remains unclear. Furthermore, the specific role of senescent fib...
Yingliang Shi, Yi Guo, Hanlin Tu et al.
· Immunity & Ageing · 0 citations