Zwitterionic Polarization-Engineering Covalent Organic Frameworks for Targeted Ferroptosis-Synergistic Photothermal Immunotherapy.
Combining efficient photocatalytic activity with precise targeting is crucial for covalent organic framework (COF)-based nanomedicines to remodel the immunosuppressive microenvironment and sensitize "cold" tumors to immunotherapy. Herein, we constructed two isomorphic frameworks featuring distinct electronic topologies...