Open access
Oct 2026
ENOPH1 orchestrates KRASG12D/G13D-driven glycolytic reprogramming and colorectal cancer progression through modulating the TGF-β/SMAD pathway.
Oncogenic KRAS mutations (G12D/G13D) drive metabolic reprogramming in colorectal cancer (CRC), yet targetable downstream effectors remain poorly defined. Here, we identify enolase-phosphatase 1 (ENOPH1) as an essential transducer directly upregulated by the KRAS-MEK-ERK axis. ENOPH1 is markedly elevated in KRAS-mutant...
Xin Chen, Yi-Ren Su, Zhi-Zhan Ni et al.
· International Immunopharmaco... · 0 citations