PEG-Lipid Interfacial Architecture Enables Zn2+-Dependent Redistribution of LNP-Mediated mRNA Expression Toward the Spleen.
PEG-lipid interfaces influence LNP nano-bio interactions, yet conventional PEG-lipid formulations differ simultaneously in several molecular features that complicate attribution of ion-dependent effects. Here, using structurally defined DMA-PEG16-OMe as a discrete PEG-lipid model and conventional DMA-PEG2k-OMe as a com...