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Author

Jie Chen

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Open access Sep 2026

Amniotic-fluid metabolomics identifies phospholipid remodeling as a metabolic signature of intrauterine exposure in pregnancies with polycystic ovary syndrome

Amniotic fluid from pregnancies with polycystic ovary syndrome showed a distinct metabolic profile dominated by lipid remodeling, identifying phospholipid remodeling as a major amniotic-fluid metabolic signature of polycystic ovary syndrome-related intrauterine exposure.

Shi-Ming Wu, Jia-Yu Shi, Chen-Yan He et al. · 0 citations
Open access Jul 2026

Blunted Lsm14b activation disrupts maternal mRNA remodeling during the GV-to-MII transition in a mouse model of polycystic ovary syndrome

Introduction Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility and is consistently associated with poor oocyte developmental competence, yet the molecular basis of this qualitative defect remains poorly defined. Because the germinal vesicle (GV)-to-metaphase II (MII) transition occurs und...

Wen-Chen Du, Jia-Yu Shi, Jie Chen et al. · 0 citations

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