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Open access Aug 2026

Deciphering the Potential Mechanism of Cordycepin in Alleviating Ulcerative Colitis via the AKT1 Signaling Pathway: An Integrated Approach Combining Network Pharmacology, Molecular Docking, and Experimental Validation

Aim Given the limited availability of safe and effective treatments for inflammatory bowel disease (IBD), we applied an integrated network pharmacology approach to systematically map the targets and pathways of cordycepin, a bioactive compound from Cordyceps militaris, in experimental colitis. Methods Cordycepin was ad...

Wenting Zhang, Min-Yan Qian, Wen-Wei Jiang et al. · 0 citations
Open access Aug 2026

From compounds to mechanism: unveiling the therapeutic action of Rudijinniuding on herpes zoster via integrated UPLC-Q/TOF-MS, network pharmacology, and molecular dynamics analyses

Rudijinniuding (RDJND), a proprietary formulation developed by Guangdong Provincial Hospital of Chinese Medicine, has demonstrated favorable anti-inflammatory and analgesic effects when applied in herpes zoster (HZ). However, its specific bioactive composition and underlying mechanisms remain unclear. The major constit...

Zhuoyue Song, Chengcheng Ge, Jie Chen et al. · 0 citations

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