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Author

Jie Feng

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Open access Jul 2026

Hydrophobic Tail and Linker Diversification of PEG-Lipids Unlocks Precise Muscle Tropism of mRNA-Lipid Nanoparticles.

A 45-member PEG-lipid library is constructed via Ugi/Passerini reactions, keeping the PEG chain constant at 2 kDa while systematically diversifying the hydrophobic tail and linker structures, establishing a translatable platform for safer, more effective mRNA vaccines and therapeutics.

Bing-Qian Ou, Xuying Tang, Sunxiang Qian et al. · 0 citations

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