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Sep 2026

A Spatially Controlled Glioblastoma-on-a-Chip for Dissecting Tumor-Immune-Vascular Crosstalk and Bevacizumab Resistance.

Glioblastoma (GBM) is an aggressive brain malignancy with a median survival of only 15 months despite current therapeutic interventions. A major obstacle to effective treatment is the intricate tumor microenvironment (TME), which drives tumor progression and therapy resistance. However, existing in vitro models lack mi...

Zi-Xuan Wang, Jie Gao, Junned Chan et al. · 0 citations
Sep 2026

The miR-6538 in extracellular vesicles derived from lycorine-pretreated mesenchymal stem cells enhances therapeutic efficacy in rheumatoid arthritis.

Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) were engineered as a targeted platform for Lycorine (LYC), a natural isoquinoline alkaloid with anti-inflammatory and anti-neoplastic properties that exhibits therapeutic potential in inflammatory diseases but is limited by systemic toxicity in clinical app...

Wu-Yan Zheng, Xiong-Fei Xu, Chen-Xu Yang et al. · 0 citations

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