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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Jie Li

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2 papers indexed here

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Open access Sep 2026

NAE1-Dependent Protein Neddylation Preserves Endothelial Identity and Vascular Integrity

Background Endothelial dysfunction is a central driver of cardiovascular and inflammatory diseases, yet the post-translational mechanisms that preserve endothelial homeostasis remain incompletely understood. Protein neddylation, the covalent conjugation of a ubiquitin-like modifier, regulates diverse cellular processes...

Rachelle Nelson Zoni, Fatema Yeasmin Tanni, Chang-Min Lee et al. · 0 citations
Open access Sep 2026

GTP biosynthesis is a therapeutic vulnerability in Rac1-mutant melanoma

Metastatic melanoma remains highly lethal despite advances in immunotherapy and MAPK-targeted therapy. The Rac1P29S mutation, present in 4-9% of cutaneous melanomas, confers intrinsic resistance to BRAF and MEK inhibitors. Like other small GTPases, Rac1 lacks suitable pockets for small molecule inhibitor binding, motiv...

S. E. Simon, Tian-Nan Wang, Arsha Sreekumar et al. · 0 citations

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