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Author

Jie Ran

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Open access Sep 2026

Hyperglycemic stress aggravates diabetic retinopathy and nephropathy by promoting cilium disassembly via a deacetylation- and methylation-mediated regulatory mechanism

Primary cilia are essential microtubule-based sensory organelles, and their dysfunction has been increasingly linked to metabolic stress. However, the underlying molecular mechanisms remain poorly understood. Herein, we reveal that ciliary defects in retinal photoreceptors and renal tubules exacerbate tissue damage dur...

Jie Ran, Chang-Feng Wei, Yang Yang et al. · 0 citations
Open access Aug 2026

CFAP100 forms phase-separated condensates required for ciliary transition zone assembly

Cilia are microtubule-based cellular protrusions critical for cell signaling and motility. The ciliary transition zone connects axonemal microtubules to the ciliary membrane and functions as a gatekeeper by regulating selective targeting and sorting of proteins. However, the molecular mechanisms underlying its assembly...

Shuang Sun, Ke-Ke Li, Xia-Oou Sun et al. · 0 citations

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