Author

Jie Wei

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Review Open access Aug 2026

Biosynthesis and Microbial Production of Carminic Acid: From Pathway Elucidation to Synthetic Biology

Key challenges for industrial translation are highlighted, including low titers, incomplete enzyme characterization, host–pathway incompatibility, and scalable purification, and propose integrated strategies combining precursor-pathway rewiring, AI-assisted enzyme engineering, biosensor-based regulation, and process op...

Hong-Yu Li, Jia-Qi Liu, Jia-Shan Lu et al. · Microorganisms · 0 citations

Review Open access Aug 2026

Self-Resistance as a Functional Beacon: Target-Directed Microbial Genome Mining from Classical Discovery to Automated Pipelines

This review summarizes the biological basis, workflow, representative advances, and limitations of self-resistance-gene guided discovery as a target-directed genome mining framework supported by tools and databases including ARTS, FunARTS, antiSMASH, and MIBiG.

Jiaxin Wu, Meng-Xue Qiao, Ya-Yue Ma et al. · Microorganisms · 0 citations