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Author

Jie Xu

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Aug 2026

Discovery of 2, 4-disubstituted pyrimidine derivatives as selective HIPK2 inhibitors for potential treatment of chronic kidney disease.

AF-1 and AF-2 represent antifibrotic candidates with a new chemical scaffold, submicromolar HIPK2 inhibitory activity, and improved subtype selectivity within the HIPK family for the treatment of CKD-associated renal fibrosis.

Xinlan Hu, Hanyi Ouyang, Chunyu Feng et al. · 0 citations

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