Review
Open access
Sep 2026
HMGB1 functional plasticity in neurodegenerative diseases and its translational implications
High mobility group box 1 (HMGB1) is a chromatin-associated protein that can be redistributed and released during cellular stress, when it acts as an extracellular alarmin within the broader family of damage-associated molecular patterns (DAMPs). Its functions depend on subcellular localization, redox and post-translat...
Wei-Cai Cai, Ya-Qiao Yi, Rong Zeng et al.
· Frontiers in Immunology · 0 citations