Author

Jie-yun Xia

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Open access Sep 2026

HDAC1 maintains metabolic homeostasis in nucleus pulposus cells via post-translational modification interactions with YBX1

Intervertebral disc degeneration is characterized by the metabolic dysregulation of nucleus pulposus cells, which is regulated by complex post-translational modifications, manifesting as extracellular matrix remodeling and inflammatory microenvironment formation. We demonstrated the progressive downregulation of HDAC1...

Bo Zhou, Jie-Yun Xia, Zhao-Wei Zhang et al. · Experimental and Molecular M... · 0 citations

Jul 2026

The USP5-MATN3 axis in nucleus pulposus cell senescence: A Deubiquitination mechanism protecting against intervertebral disc degeneration.

This study clarifies the molecular mechanism by which the USP5/MATN3 axis regulates cellular senescence and affects IVDD progression, opening up new potential targets for the intervention strategy of IVDD.

Chunyang Fan, Jie-yun Xia, Yao Zhang et al. · Cellular Signalling · 0 citations