Open access
Aug 2026
ATF4 and FGFR4 cooperatively support thyroid cancer progression and CAF-associated tumor-promoting features
In vivo, ATF4 and/or FGFR4 silencing suppressed xenograft growth, increased tumor apoptosis, and reduced CAF-associated marker expression may contribute to cancer cell aggressiveness and to the maintenance of a CAF-associated tumor-promoting microenvironment.
Jinsong Zhang, Jiehao Cai, Wei-Hong Ruan
· Endocrine · 0 citations