Open access
Jul 2026
Coronavirus papain-like protease antagonizes innate immunity by cleaving Importin α1 to disrupt nuclear transport
The PLpro-TM protein is identified as a pan-coronavirus antagonist of nucleocytoplasmic trafficking and innate immune response and established PLpro-TM-mediated cleavage of Importin α1 as a conserved immune evasion strategy across coronaviruses and highlights this interaction as a potential target for broad-spectrum an...
Jie-Huang Wang, Wenxiang Xue, Ying-Jie Sun et al.
· bioRxiv · 0 citations