Author

Ji-Feng Zhang

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Jul 2026

PTEN Negatively Regulates Spastin Ser210 Phosphorylation To Modulate GluA1 Surface Trafficking and Excitatory Synaptic Transmission.

As a key component of the cytoskeleton, microtubule dynamics provide structural support for neurite growth. Spastin plays a critical role in reshaping microtubule arrangement, which is essential for axon development and regeneration. However, the mechanism by which spastin is activated and functions remains unclear. In...

Danlei Liu, Jiagui Zhong, Laijian Wang et al. · ACS Chemical Neuroscience · 0 citations

Open access Jul 2026

Social isolation disrupts prefrontal excitatory-inhibitory balance to impair social novelty memory in adult male mice.

It is established that adult social isolation disrupts social novelty memory processing by shifting the mPFC excitatory-inhibitory balance toward a net hyperexcitable state, revealing a reversible, circuit-specific mechanism for isolation-induced social cognitive deficits.

Quan Yuan, Bing-Yu Ren, Laijian Wang et al. · Translational Psychiatry · 1 citation