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Jih-Yun Lee

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Open access Sep 2026

Structure-based analysis reveals a hydrophobic pocket governing P2Y12 receptor agonist potency and selectivity.

Agonist of the ADP-activated P2Y12 receptor modulate platelet aggregation and microglial function, yet the structural basis of their potency and selectivity remains unclear. Using recent active-state cryo-EM structures of P2Y12 and P2Y1 receptors, we applied an integrated modelling approach to revisit a structurally un...

Matteo Pavan, Jih-Yun Lee, John C. Hancock et al. · 0 citations

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