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Jill K. Morris

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Sep 2026

Chronic mitochondrial DNA depletion alters MAPT splicing and increases tau levels.

BackgroundIn Alzheimer's disease (AD), tau protein aggregates to form neurofibrillary tangles (NFTs). The cellular changes favoring AD brain NFT formation remain incompletely understood. AD brains also display mitochondrial defects, including reduced mitochondrial DNA (mtDNA) copy number.ObjectiveWe considered whether...

Ian Weidling, E. Schueddig, Xiao-Wan Wang et al. · 0 citations

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