Repair of large segmental bone defects requires implanted scaffolds not only to provide sufficient structural stability but also to accommodate the pronounced spatial heterogeneity, anisotropy, and load-dependent nonlinear behaviour of native bone while establishing a local mechanical microenvironment conducive to tiss...
Xing-Zhen Li, Jin-Bo Zhang, Hao Chen et al.· International Journal of Bio...· 0 citations
The central challenge in bone tissue engineering is not merely to fabricate bone-like materials, but to reconstruct a regenerative microenvironment that recapitulates native bone. Decellularized extracellular matrix (dECM) retains tissue-specific structural components and biological cues and is therefore regarded as a...
Quezhu Danzeng, Yu-Qiang Wang, Jin-Bo Zhang et al.· International Journal of Bio...· 0 citations
The tendon–bone interface anchors compliant tendon to rigid bone through continuous gradients in collagen orientation, proteoglycan content, mineralization, and local modulus. After adult injury, this spatiotemporal organization is difficult to restore, and repair typically produces a fibrous connection rather than a f...
Zhao-Wei Zhang, Hao Chen, Jin-Bo Zhang et al.· International Journal of Bio...· 0 citations
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