Author

Jin-Feng Wu

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Open access Sep 2026

UPF1-dependent glycolysis driven by LINC00887 facilitates macrophage M2 polarization in clear cell renal cell carcinoma

Introduction LINC00887 plays critical roles in tumor biology, from oncogenesis to metastasis and drug resistance, while the specific mechanism in ccRCC remains unclear. We analyzed the expression profiles of LINC00887 and UPF1 and assessed their correlation with glycolytic activity and M2 macrophage infiltration. Metho...

Jia-Yue Wu, Jia-Wen Wang, Jing-Yu Weng et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

FKBP52 dictates the dual role of p53 in hepatocellular carcinoma: Mutation-specific prognostic stratification and therapeutic implications

These findings establish FKBP52 as a novel p53 stabilizer with context-dependent oncogenic effects, critically determined by p53 mutational status, and highlight the therapeutic potential of targeting the FKBP52-MDM2-p53 axis specifically in TP53-mutant HCC.

Jin-Feng Wu, Cheng-Yan Tang, Z. Meng et al. · Journal of Biological Chemis... · 0 citations