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Open access Aug 2026

Loss of wbp11 causes multi-system developmental defects: a zebrafish model of VACTERL association

Introduction VACTERL association is a congenital disorder characterized by the non-random co-occurrence of vertebral, anal, cardiac, tracheo-esophageal, renal, and limb anomalies. WBP11 has been identified as a candidate causative gene; however, existing heterozygous Wbp11 knockout mice recapitulate only a subset of th...

Yu Chen, Shiqi You, Ying-Shuo Zhang et al. · 0 citations
Review Open access Aug 2026

Emerging molecular mechanisms of the ECM–exosome growth-plate axis in idiopathic short stature

Idiopathic short stature (ISS) remains a clinically heterogeneous diagnosis in which impaired linear growth is often defined by exclusion rather than by mechanism. Increasing evidence suggests that ISS and related short-stature phenotypes may converge on overlapping growth-plate abnormalities characterised by disrupted...

Li-Zhen Piao, Hong Wang, Qiu-Ying Zhang et al. · 0 citations

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