Ferroptosis is implicated in multiple human diseases, but the lack of bioavailable inducers has limited its physiological study and therapeutic translation. Here, we report KY0418, a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) featuring an isourea warhead, with high plasma stability and broad tissue...
Nathchar Naowarojna, Xin Gu, Zi-Jian Pan et al.· Cell· 0 citations
This work demonstrates that the UT3 domain of Ufd1 interacts simultaneously with two Lys48-linked ubiquitins and unfolds one of the ubiquitins by binding its C-termianl β-strand into a cleft and establishes a linkage-specific recognition that involves ubiquitin unfolding.
Yan-Zhu Wang, Zhi-Min Zhang, Wei He et al.· bioRxiv· 1 citation
It is demonstrated that the UT3 domain of Ufd1 specifically interacts with two K48-linked ubiquitins and unfolds one of the ubiquitins by binding its C-terminal β-strand into a conserved hydrophobic cleft and is captured by Npl4 and Cdc48/p97.
Yan-Zhu Wang, Zhi-Min Zhang, Wei He et al.· Nature Structural & Molecula...· 0 citations
It is reported that, independent of its catalytic function, the glycolytic enzyme PGAM1 acts as a scaffold protein to regulate autophagy activation, thereby modulating cellular homeostasis and stress response.
Yi Zhang, Peng-Wei Zhao, Hang-Fei Liang et al.· Nature Cell Biology· 1 citation
Divergence in cis-regulatory elements and subcellular targeting, in the absence of protein function modification, were potent drivers of metabolic evolution, providing a strategy for re-engineering valuable chemical diversity into cultivated crops.
