Author

Jin Heon Jeon

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Open access Aug 2026

A cryptic allosteric pocket shapes isoform‐selective inhibition of human malic enzymes

Malic enzymes (ME) regulate central carbon metabolism and cellular redox balance, and the mitochondrial isoform ME2 is frequently upregulated in aggressive cancers to support metabolic flexibility and stress resistance. Isoform‐selective inhibition has remained out of reach because the catalytic machinery is essentiall...

Ben A. Krinkel, Y. Yosaatmadja, M. Slayton et al. · Protein Science · 0 citations

Jul 2026

Abstract B089: Targeting metabolic vulnerabilities in cancer through structure-guided discovery of novel malic enzyme inhibitors

These findings establish mitochondrial malic enzymes, particularly ME2/ME3, as tractable metabolic targets for cancer therapy, and provide a strong foundation for rational optimization of potency and isoform selectivity.

Ben A. Krinkel, Y. Yosaatmadja, M. Slayton et al. · Clinical Cancer Research · 0 citations