Diffuse gastric cancer (DGC) is an aggressive gastric cancer subtype with a poor prognosis. The RHOA Y42C mutation is recurrent in DGC, but its independent oncogenic role is unclear. Next-Generation Sequencing of 431 DGC cases revealed that most RHOA mutations occurred without CDH1 alterations. Using genetically engine...
Kyung-Pil Ko, Sangmin Kim, Jin-Ho Jang et al.· Nature Communications· 0 citations
Cancer cell plasticity, the ability of tumor cells to switch between distinct cellular states, has emerged as a key mechanism driving tumor progression, metastasis and therapy resistance. Cancer cells exploit diverse plasticity mechanisms, including dedifferentiation, transdifferentiation, epithelial-mesenchymal transi...
Yoojeong Seo, Jin-Ho Jang, Jae-Il Park· Experimental and Molecular M...· 0 citations
It is shown that loss of the actin polymerization regulator CRACD promotes mucinous plasticity and immune escape by driving hypoxia-dependent upregulation of PD-L1.
Yoojeong Seo, Jin-Ho Jang, Kyung-Pil Ko et al.· Nature Communications· 0 citations
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