Open access
Sep 2026
TMEM39A acts as a novel profibrotic factor to activate hepatic stellate cells partially via the cell adhesion molecule signaling axis
Hepatic stellate cell (HSC) transdifferentiation into myofibroblasts is a pivotal event in liver fibrosis, yet the underlying regulatory network remains elusive. This study explores the role of TMEM39A in HSC activation and its pro-fibrotic effects via the cell adhesion molecule (CAM) signaling axis. An i...
Meng Kong, Li-Hong Zhang, Yue-Xia Bai et al.
· Frontiers in Cell and Develo... · 0 citations