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Author

Jinhui Wang

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Open access Aug 2026

Bacteria-Mediated Targeted Delivery and Deep Tumor Penetration of a Pt(IV)-Drug Enables Synergistic Chemo-Immunotherapy.

Platinum-based drugs are clinically vital for cancer treatment but suffer from off-target cytotoxicity and poor tumor penetration. To overcome these limitations, we designed a tumor-targeted Pt(IV) drug-bacteria conjugate (Pt-EcN-HER2). This conjugate exploits the inherent tumor tropism of probiotic bacterium Escherich...

He Meng, Jin-Hui Wang, Bing Shi et al. · 0 citations
Aug 2026

Regulation of the Staphylococcus aureus stress response pathway by copper ions.

It is demonstrated that copper-associated oxidative perturbation modulates the DNA-binding activity of CtsR through a conserved cysteine residue, consistent with a copper-associated Cys37-dependent redox mechanism potentially coupling metal homeostasis, oxidative stress, and proteostasis regulation in S. aureus.

Yufang Xiong, Kai Lu, Yu-Xiang Lu et al. · 0 citations

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