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Open access Oct 2026

FOXA1-driven transcription and TRIM9-mediated ubiquitination of LCN2 modulate ferroptosis in experimental sepsis-induced acute lung injury

Sepsis-induced acute lung injury (ALI) remains a devastating complication of sepsis, marked by uncontrolled pulmonary inflammation, alveolar-capillary barrier disruption, and high mortality. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, is implicated in sepsis-related org...

Jin Li, Ya-Zhou Li, Chun-Tao Song et al. · 0 citations
Open access Sep 2026

A Hypoxia Associated STC2 High Endothelial Subpopulation is Linked to Lipid Metabolic Reprogramming, Pathological Angiogenesis, and Immune Remodeling in Head and Neck Squamous Cell Carcinoma

Purpose Hypoxia drives malignant advancement and immune escape in HNSCC, but its cell‑type‑specific regulatory circuitry within the TME remains insufficiently elucidated. This study systematically characterizes hypoxia‑associated molecular programs and identifies core genes with relevance to prognosis and therapeutic r...

Kang-Ying Chen, Lu-Ying Qin, Zhi-Chao Liu et al. · 0 citations

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