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Author

Jin Li

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Open access Sep 2026

An H2A.Z-dependent epigenetic checkpoint in macrophages couples genetic risk to microbial metabolite signaling.

H2A.Z deposition functions as an acylation-dependent epigenetic checkpoint that couples macrophage differentiation to inflammatory resolution, integrating host genetics and microbial metabolites to calibrate immune responses.

Zhao-Ran Sun, Fan-Yi Meng, Chun-Jian Piao et al. · 0 citations
Open access Aug 2026

Shared genetic architecture and therapeutic targets across paediatric immune-mediated diseases.

Paediatric IMIDs shared broad polygenic architecture with adult IMIDs, whereas top-ranked genes converged strongly with adult rheumatic diseases, providing a genomic framework for paediatric precision medicine, guiding classification, risk prediction, and therapeutic development.

Jin Li, Hui-Qi Qu, Michael E. March et al. · 0 citations

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