Sep 2026
Targeting IGF2BP3-driven CSF1/CSF1R signaling disrupts the positive feedback loop between tumor cells and macrophages and inhibits HCC progression.
It is revealed that IGF2BP3 drives HCC malignancy by establishing a reciprocal interaction between tumor cells and macrophages via the CSF1/CSF1R signaling pathway, highlighting that therapeutic targeting of this axis may disrupt tumor-macrophage crosstalk and improve therapeutic efficacy.
Xiao-Ying Ji, Lin-Ran Zhang, Xiao-Xiao Zhu et al.
· Life Science · 0 citations