Combined hydrogen and oxygen therapy attenuates vascular cognitive impairment in rats via gut microbiota-derived SCFA-GPR41/PI3K/Akt/Nrf2 signaling
Vascular cognitive impairment (VCI), a consequence of chronic cerebral hypoperfusion (CCH), is characterized by neuroinflammation and neuronal apoptosis. Hydrogen-rich and hyperoxygenated solution (HHOS) may attenuate CCH-induced brain injury through antioxidant, anti-inflammatory, and gut microbiota-modulating mec...