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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Jin-Wu Zhao

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Open access Sep 2026

Macrocyclization of native peptides through (thio)urea crosslinking of two amines

Cyclopeptides have emerged as promising candidates for drug development. However, owing to the scarcity of efficient cyclization strategies for natural peptides, the development of diverse cyclopeptides remains a formidable challenge. In this study, a variety of macrocyclic peptides featuring (thio)urea bridges are dev...

Jin-Yao Liu, Pei-Ru Chen, Mei-Lin Tang et al. · 0 citations
Aug 2026

Triazine Linchpins for Selective Lys-Lys Stapling of Unprotected Peptides.

Peptide stapling exerts profound effects on key peptide properties, including metabolic stability, cell membrane permeability, and conformational constraint. Herein, we report a mild and efficient 2,4-dichloro-1,3,5-triazine-mediated stapling strategy for the selective cross-linking of lysine side-chain amines. This ap...

Pei-Ru Chen, Anhui Mao, Jing-Xiu Xu et al. · 0 citations

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