Redox Reprogramming of the Tumor Microenvironment: Targeting Extracellular ROS to Restore Antitumor Immunity
Reactive oxygen species (ROS) are central regulators of redox homeostasis yet exert paradoxical effects in cancer. While ROS overproduction can directly kill tumor cells, persistent oxidative stress in the tumor microenvironment (TME) paradoxically impairs antitumor immunity. Excess extracellular ROS oxidize critical...