Jin-Yao Liu

Macrocyclization of native peptides through (thio)urea crosslinking of two amines

Cyclopeptides have emerged as promising candidates for drug development. However, owing to the scarcity of efficient cyclization strategies for natural peptides, the development of diverse cyclopeptides remains a formidable challenge. In this study, a variety of macrocyclic peptides featuring (thio)urea bridges are dev...