Open access
Sep 2026
Identifying a broad-spectrum influenza inhibitor that blocks multiple functions of viral NS1 protein
Nonstructural protein 1 (NS1) is the key virulence factor of influenza A virus (IAV) that affects the replication and pathogenicity of IAV, which can be used as a promising anti-IAV target. Herein, we identify a marine derived NS1 inhibitor HDN2398 with broad-spectrum anti-IAV effects in different cell lines and female...
Yang Zhang, Ya-Min Luo, Wen-Rui Gai et al.
· Nature Communications · 0 citations