Mechanically adaptive dual-crosslinked hydrogel integrated with metal-phenolic cell backpacks for active keloid therapy.
Keloids are invasive, highly recurrent fibroproliferative disorders. Clinical samples reveal a pathological pattern characterized by dysregulated extracellular matrix (ECM) remodeling, reduced NK-cell infiltration, and elevated TGF-β1. Current monotherapies have limited efficacy, and local delivery systems fail to achi...