Jinchao Jia

mRNA-encoding CD19-targeting T cell engager for refractory immune thrombocytopenia.

In a first-in-human study involving three patients with refractory secondary immune thrombocytopenia, ABO2203 achieved rapid and complete peripheral B cell depletion, with sustained depletion in bone marrow, establishing mRNA-encoded TCEs as a potent and safer therapeutic modality for B cell-mediated autoimmune disease...