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Jing-Chen Xu

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Open access Aug 2026

hnRNPC facilitates coronavirus replication by directly binding the frameshift-stimulatory element of viral genomic RNA

HnRNPC is identified as a key host cofactor for coronaviruses and provides a novel target for broad-spectrum antiviral drug development and the small molecule Elbasvir directly binds hnRNPC, disrupting the interaction between hnRNPC and FSE RNA and inhibiting coronavirus replication by decreasing –1 PRF efficiency.

Jing-Chen Xu, Hong-Ying Li, Jian-Rui Li et al. · 0 citations

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