Author

Jing Dong

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Open access Oct 2026

Mitochondrial genetic variation as a novel predictor of graft-versus-host disease after stem-cell transplantation in myelodysplastic neoplasms

Graft-versus-host disease (GvHD) remains a major cause of morbidity and non-relapse mortality after allogeneic hematopoietic cell transplantation. Building on prior evidence implicating mitochondrial DNA (mtDNA) variation in myelodysplastic neoplasms (MDS), we investigated the prognostic impact of recipient and donor m...

Shahram Arsang-Jang, Tao Zhang, M. Rafati et al. · Journal of Hematology & Onco... · 0 citations

Open access Oct 2026

Germline DDX41 defines a distinct subgroup in MDS undergoing transplantation with reduced relapse and improved survival.

Germline DDX41 variants are a recognized cause of adult myelodysplastic neoplasms (MDS), characterized by distinct biological features and favorable prognosis. The independent effect of DDX41 status on outcomes after allogeneic transplantation, the role of conditioning intensity, and treatment-related toxicity risk rem...

N. Gagelmann, Christopher R. Reilly, Archana Sasi et al. · Blood · 0 citations

Open access Sep 2026

Mitochondrial Genomic Alterations in Pediatric Acute Lymphoblastic Leukemia: Implications for Methotrexate‐Induced Neurotoxicity and Ethnic Disparities

Methotrexate (MTX)‐induced neurotoxicity is a serious complication in pediatric acute lymphoblastic leukemia (ALL), with observed ethnic disparities in risk. To investigate the role of mitochondrial DNA (mtDNA) variation, we performed whole mtDNA sequencing in 94 children with ALL, including 62 Hispanic patients. We id...

Jing Han, Shahram Arsang-Jang, Paul L. Auer et al. · Cancer Medicine · 0 citations