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Open access 2026

Topology-enabled long-acting interleukin-2 for advanced low-dose interleukin-2 therapy of autoimmune diseases

The therapeutic efficacy of protein biologics is often hampered by their rapid in vivo degradation and off-target effects. Interleukin-2 (IL-2), a cytokine promising for treating autoimmune diseases via regulatory T cell (Treg) expansion, exemplifies this challenge due to its short half-life and pleiotropic activity. H...

Jing Fang, Rui-Ling Feng, Xi-Bao Tian et al. · 0 citations
Aug 2026

Low-dose interleukin-2 combined with thalidomide for a severe cutaneous immune-related adverse event associated with PD-1/CTLA-4 bispecific antibody therapy: a case report.

The case of a patient with gastric cancer who developed rapidly progressive erythema and pruritus after treatment with iparomlimab and tuvonralimab is reported, and clinical improvement was observed within 48 hours, with complete resolution of the skin lesions at 2 weeks.

Zhi-Qiang Li, Yufei Li, Yuhan Zhang et al. · 0 citations

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