Author

Jing-Hua Yang

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Open access Oct 2026

Jian'er Jiedu granule alleviates acute lung injury via NOD2/NF-κB/NLRP3 axis: Network pharmacology, machine learning, and experimental validation.

BACKGROUND Acute lung injury (ALI) is a severe inflammatory disorder associated with high mortality. Jian'er Jiedu granule (JEJD), a formulation developed by Guangdong Provincial Hospital of Traditional Chinese Medicine, has shown promise in alleviating Omicron-related symptoms; however, its therapeutic effects on ALI...

Lai-Jun Yang, Xiao-Lu Wang, Yi Guo et al. · International Immunopharmaco... · 0 citations

Review Open access Aug 2026

A protracted diagnostic journey of pediatric PAPA syndrome and subsequent response to tofacitinib therapy: a case report and literature review

PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) is a rare autosomal dominant autoinflammatory disorder caused by mutations in the PSTPIP1 gene. In pediatric patients, arthritis often precedes cutaneous manifestations by several years, leading to frequent misdiagnosis as septic arthritis. Trea...

Shui-En He, Hao Deng, Jing-Hua Yang et al. · Frontiers in Immunology · 0 citations

Review Open access Aug 2026

Syndrome differentiation and treatment of pediatric central precocious puberty: role of the spleen-kidney axis

The role of kidney and spleen dysfunction is discussed and the underlying mechanisms are explored – particularly in the context of the neuro-endocrine-immune network that links central neuroendocrine activation with peripheral immune-metabolic signals.

Yu-Jun Luo, Chao-Jie Huang, Yanbing Lu et al. · Frontiers in Immunology · 0 citations