Jing-Jing Ma

Kurarinone protects against neuronal ferroptosis and restores iron homeostasis through an ERα-associated NRF2/FTH1 pathway in cellular and animal models of Parkinson’s disease

Parkinson’s disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra. Increasing evidence suggests that ferroptosis, an iron-dependent form of lipid peroxidation-driven cell death, contributes to PD pathogenesis. Kurarinone (KUR), a major prenylated flavonoid...