Jing-Jing Mao

Dkk3-Cyp11b2/aldosterone signaling couples ion-homeostatic failure to mitochondrial apoptosis in cochlear aging.

Cellular responses to aging require coordinated control of extracellular signaling, ion transport, redox balance, and mitochondrial metabolism. Here, we identify Dickkopf-3 (Dkk3) as an age-associated signal linked to the Cyp11b2/aldosterone pathway in cochlear sensory cells. Exploratory analysis of a public cell-type-...