PANoptosis, an inflammatory programmed cell death that integrates pyroptosis, apoptosis, and necroptosis, holds great promise for cancer immunotherapy. However, conventional strategies relying on PANoptosome assembly are hindered by complex upstream signaling requirements. Here, we report P-CHD-TPP, an enzyme-instructe...
Rapid cellular clearance severely restricts the effective analytical and functional windows of intracellular probes. Herein, we developed an endogenous enzyme-driven adaptive DNA nanomachine (TRZL) that synchronizes target recognition with in situ morphological transformation to overcome premature cellular clearance...
Xiao-Qiong Li, Ye Zhu, Zhi-Fan Ye et al.· Analytical Chemistry· 0 citations
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