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Author

Jing-Juan Xu

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Open access Oct 2026

Enzymatic In Situ Self-Assembly of a Fluorogenic Photosensitizer Induces PANoptosis for Photodynamic-Immunotherapy.

PANoptosis, an inflammatory programmed cell death that integrates pyroptosis, apoptosis, and necroptosis, holds great promise for cancer immunotherapy. However, conventional strategies relying on PANoptosome assembly are hindered by complex upstream signaling requirements. Here, we report P-CHD-TPP, an enzyme-instructe...

Yu-Yang Tian, Peng-Ke Zhao, Meng-Xian Ling et al. · 0 citations
Oct 2026

APE1-Responsive Adaptive DNA Nanomachines for Prolonged Intracellular Bioanalysis and Sustained Gene Silencing

Rapid cellular clearance severely restricts the effective analytical and functional windows of intracellular probes. Herein, we developed an endogenous enzyme-driven adaptive DNA nanomachine (TRZL) that synchronizes target recognition with in situ morphological transformation to overcome premature cellular clearance...

Xiao-Qiong Li, Ye Zhu, Zhi-Fan Ye et al. · 0 citations

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